Abcam, ab68041, Anti-Kindlin-1 antibody

Size: 100µg
Rabbit Polyclonal Kindlin-1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 19 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kindlin-1 also known as FERMT1 is a protein that plays an important role in integrin-mediated cellular functions. It has a molecular mass of about 75 kDa and is mainly expressed in epithelial cells particularly in the skin and intestine. The Kindlin-1 protein assists in activating integrins by binding to their tails and facilitating integrin-ligand interactions on the cell surface which are important for cell adhesion and signal transduction.
Biological function summary
Kindlin-1 influences cell adhesion migration and proliferation. It is a component of a complex that includes talin another integrin activator which stabilizes interactions at the cell matrix interface. The Kindlin-integrin interaction impacts actin cytoskeleton remodeling an important step for maintaining the structural integrity and functions of epithelial tissues. The proper functioning of Kindlin-1 in cellular dynamics ensures tissue homeostasis and repair.
Pathways
Kindlin-1 is involved in the integrin signaling pathway and the focal adhesion pathway. Integrin signaling is essential for transmitting mechanical and chemical signals from the extracellular matrix into the cell influencing cellular responses. The cooperation with proteins like talin and paxillin in these pathways highlights Kindlin-1’s role in regulating cell movement and mechanical sensing. These pathways contribute to pathological and physiological processes including wound healing and tissue morphogenesis.
Mutations in the Kindlin-1 gene link to Kindler Syndrome a rare autosomal recessive disorder. This condition affects the skin’s ability to repair itself and causes photosensitivity and skin blistering. Additionally Kindlin-1 is connected to inflammatory bowel disease due to its presence in intestinal epithelial cells. Alterations in Kindlin-1 expression or function can disrupt the balance of integrin-mediated adhesion impacting interactions with other components like collagen and impacting epithelial integrity therefore bearing relevance in the context of these disorders.