Abcam, ab68547, Anti-CPNE7 antibody [CPNE7-01]

Size: 100µg
Mouse Monoclonal CPNE7 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CPNE7.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CPNE7-01,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CPNE7. The exact immunogen used to generate this antibody is proprietary information.Q9UBL6,
Specificity:ab68547 recognizes C terminus of human CPNE7.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.098% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CPNE7 also known as copine-7 is a protein with a molecular weight of approximately 64 kDa. It belongs to the copine family which includes calcium-dependent membrane-binding proteins. CPNE7 contains C2 domains which allow it to interact with phospholipids in a calcium-dependent manner. This protein is highly expressed in neuronal tissues like the brain but you can also find it in other tissues at lower levels. Its expression suggests a role in cellular processes that require precise regulation by calcium.
Biological function summary
CPNE7 modulates cellular mechanisms involved in signal transduction and membrane trafficking. It does not currently belong to a specific multi-protein complex but it interacts dynamically with other membrane-associated proteins due to its phospholipid-binding ability. CPNE7 plays a role in regulating neuronal growth and differentiation which are essential processes for maintaining proper brain function. Additionally its involvement in cell adhesion suggests a part in tissue repair and cellular communication.
Pathways
Calcium signaling and the phosphatidylinositol signaling pathway are two important ones involving CPNE7. This protein interacts with other calcium-binding proteins in the pathways to mediate signal transduction processes. CPNE7 regulates interactions among phospholipids and affects cellular responses to external stimuli. It modulates activity of proteins like protein kinase C which is important for many cellular functions including growth differentiation and apoptosis.
Studies link CPNE7 to neurodegenerative diseases such as Alzheimer's disease where calcium dysregulation plays an important role. Alterations in CPNE7 function can contribute to the disease progression by affecting neuronal viability and synaptic integrity. Researchers also link CPNE7 to cancer as it participates in pathways that regulate cell proliferation and migration. Proteins such as protein kinase C could be affected by CPNE7 dysregulation in these diseases highlighting its significance in disease mechanisms.