Abcam, ab68748, Anti-EFCAB6 antibody

Size: 50µg
Mouse Polyclonal EFCAB6 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EFCAB6.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human EFCAB6.Q5THR3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EFCAB6 also known as DJBP (DnaJ homolog subfamily B member 14 binding protein) is a calcium-binding protein with a molecular mass of approximately 89 kDa. This protein features multiple EF-hand motifs that facilitate its role in binding calcium ions affecting its structural conformation and function. EFCAB6 expresses in various tissues with a notable presence in the heart brain and testis suggesting a specialized role in these locations. Its calcium-binding ability suggests involvement in processes regulated by calcium signaling.
Biological function summary
EFCAB6 plays an important role in maintaining cellular calcium homeostasis and signaling pathways. It acts as a modulator within signal transduction pathways that rely on calcium ions and sometimes it participates as part of larger protein complexes. The interaction between EF-hands and calcium allows EFCAB6 to regulate activities in the cell that rely on transient calcium variations.
Pathways
Researchers recognize EFCAB6 for its involvement in calcium signaling and the regulation of cell cycle-related pathways. It exhibits interaction with proteins such as KITLG (Kit Ligand) and CALM1 (Calmodulin 1) which play key roles in signaling pathways. Through these interactions EFCAB6 helps regulate processes important for cell division and proliferation.
EFCAB6 links with certain heart disorders and neurological conditions. Alterations in its calcium-binding capacity may contribute to irregular heart rhythms and contribute to neurodegenerative diseases. EFCAB6's interaction with proteins like CACNA1C (calcium voltage-gated channel subunit alpha1 C) and PRKCA (protein kinase C alpha) connects it to these conditions as disruptions in these interactions may lead to pathophysiological consequences.