Abcam, ab69152, Anti-CXorf21 antibody

Size: 50µg
Anti-CXorf21 antibody (ab69152) is a mouse polyclonal antibody detecting CXorf21 in Western Blot . Suitable for Human . - Trusted since 2009
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TASL.Q9HAI6

Product details:
What is this antibody validated in?
Anti-CXorf21 antibody (ab69152) is a mouse polyclonal antibody and is validated for use in Western Blot (WB) in Human samples.
What is the molecular weight of CXorf21?
Anti-CXorf21 (ab69152) specifically detects a band for CXorf21 (UniProt: Q9HAI6) at a molecular weight of 34kDa.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: 91% Water, 8% Sodium chloride, 0.6% Disodium hydrogenorthophosphate, 0.2% Potassium chloride, 0.2% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXorf21 also known as chromosome X open reading frame 21 is a protein encoded by the CXorf21 gene. This target has a molecular mass of approximately 38 kDa. CXorf21 is known to be expressed widely in human tissues with notable expression in immune-related tissues such as the spleen and peripheral blood leukocytes. It functions mechanistically in cellular processes through its role as an integral membrane protein although specific binding partners and exact cellular functions remain active areas of research.
Biological function summary
CXorf21 is involved in the modulation of immune responses. It participates in processes involving immune cell signaling and may act as a receptor or activator in immune pathways. Studies suggest that CXorf21 plays a role in the regulation of immune cell activation and cytokine production indicating its involvement in immune modulation. CXorf21 is not generally recognized as part of a larger protein complex yet it interacts with components of the innate immune system.
Pathways
CXorf21 actively contributes to immune response pathways. It has associations with Toll-like receptor signaling and the regulation of inflammatory response pathways. Through these pathways CXorf21 also interacts with proteins like MyD88 and NF-kB which are important components of the inflammatory response. These interactions suggest its role in modulating cellular responses to pathogens and inflammatory stimuli.
CXorf21 shows associations with autoimmune diseases such as lupus and rheumatoid arthritis. Research indicates that altered expression of CXorf21 might contribute to the pathogenesis of these conditions. In lupus for instance CXorf21 could be linked to an overactive immune response. Furthermore CXorf21 interactions with proteins like TLR7 known for its role in autoimmunity highlight its potential impact on disease processes.