Abcam, ab69206, Anti-PRDM15 antibody

Size: 50µg
Mouse Polyclonal PRDM15 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PRDM15.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PRDM15.P57071

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRDM15 also known as PR Domain Zinc Finger Protein 15 functions as a transcriptional regulator with a zinc finger domain. It influences gene expression through epigenetic modifications. The protein has a mass of approximately 97 kDa. Research shows that PRDM15 is expressed in pluripotent stem cells and certain tissues during early developmental stages playing a role in maintaining cellular identity.
Biological function summary
The protein participates in regulating stem cell pluripotency and differentiation. PRDM15 forms part of transcriptional complexes that modulate the expression of important developmental genes. It ensures the correct activation of target genes allowing for proper cellular function and development. Researchers have found it maintains a balance between pluripotency and differentiation during embryogenesis affecting various developmental processes.
Pathways
PRDM15 acts within the Wnt signaling pathway and also influences the Hedgehog pathway. These pathways are significant for cell differentiation and developmental processes. The protein works closely with other transcription factors such as TCF/LEF in the Wnt pathway impacting gene regulation. PRDM15 modulates the expression of pathway-specific genes linking it to several important cellular functions.
PRDM15's dysfunction associates with congenital malformations and cancer. Mutations in PRDM15 can lead to an increased risk of certain developmental disorders due to its role in embryogenesis. There is also evidence connecting PRDM15 to tumorigenesis where its dysregulation may contribute to oncogenic processes. Researchers have observed interactions with proteins like GLI1 in the context of cancer highlighting its potential role in disease pathogenesis.