Abcam, ab69296, Anti-ABCC10 antibody

Size: 50µg
Mouse Polyclonal ABCC10 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ABCC10.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ABCC10.Q5T3U5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ABCC10 protein also known as Multidrug Resistance Protein 7 (MRP7) functions as an ATP-binding cassette transporter. It contributes to multidrug resistance by extruding a variety of xenobiotics and physiological substrates out of cells. The ABCC10 protein has a mass of about 171 kDa. Researchers have found ABCC10 expression in various tissues including the liver lung and testis suggesting its diverse role in different cell types.
Biological function summary
This transporter plays critical roles in cellular detoxification processes. ABCC10 is part of the larger ATP-binding cassette (ABC) transporter family which includes other transporters like ABCC1 and ABCC2. By actively transporting drugs and organic anions across cellular membranes ABCC10 helps regulate the intracellular concentrations of these compounds and maintain cellular homeostasis.
Pathways
ABCC10 participates in the detoxification and xenobiotic metabolism pathways interacting with enzymes such as cytochrome P450s. The protein contributes to the resistance against various chemotherapy drugs by exporting them out of cells impacting the drug metabolism pathway. This function is related to other ABC transporters like ABCC1 which similarly influence drug clearance and pharmacokinetics.
ABCC10 has been implicated in cancer chemotherapy resistance. Many studies have noted that overexpression of ABCC10 correlates with reduced drug accumulation in cancer cells resulting in chemotherapy failure. Its function is also connected to the protein P-glycoprotein another drug transporter that plays a similar role in multidrug resistance highlighting the complex network of transporters involved in therapeutic resistance.