Abcam, ab69311, Anti-IMPAD1 antibody

Size: 50µg
Mouse Polyclonal IMPAD1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BPNT2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human BPNT2.Q9NX62,
Specificity:This antibody is reactive against mammalian transfected lysate.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IMPAD1 also known as Inositol Monophosphatase Domain Containing 1 is an enzyme with a molecular mass of approximately 50 kDa. The enzyme is primarily located in the Golgi apparatus of cells. It catalyzes the dephosphorylation of inositol monophosphates which is a critical step in the phosphatidylinositol signaling pathway. The expression of IMPAD1 occurs in various tissues including the brain cartilage and kidney reflecting its diverse roles in different biological functions.
Biological function summary
IMPAD1 contributes to maintaining cellular inositol balance and is involved in the regulation of signaling pathways. It does not directly participate in a complex but its activity is essential for sustaining the levels of inositol phosphates within the cell. This function is particularly significant in neural and cartilage cells where it helps in the modulation of cellular responses to external stimuli.
Pathways
IMPAD1 plays a role in the phosphoinositide signaling pathway and the inositol phosphate metabolism pathway. It works alongside other phosphatases and kinases including Inositol polyphosphate-4-phosphatase type II (INPP4B) to regulate the phosphorylation state of inositol phosphates. Through these pathways it influences the synthesis of important secondary messengers like PI(345)P3 which are important for cellular signaling processes.
IMPAD1 has been associated with chondrodysplasia with joint dislocations and neurodegenerative disorders. Mutations in the IMPAD1 gene can disrupt the inositol metabolism leading to severe skeletal abnormalities and joint issues. Additionally dysfunction in its related signaling pathways particularly through interactions with proteins like INPP4B can contribute to neurodegenerative pathologies highlighting its broad impact on human health.