Abcam, ab69447, Anti-NUP43 antibody

Size: 50µg
Mouse Polyclonal NUP43 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Nucleoporin Nup43.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Nucleoporin Nup43.Q8NFH3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NUP43 also known as nucleoporin 43 is an important component of the nuclear pore complex (NPC). Weighing approximately 43 kDa this protein is expressed in the nuclear envelope of eukaryotic cells. NUP43 is part of the Y-complex which plays a mechanical role in mediating the transport of molecules between the nucleus and the cytoplasm. Its presence in the nuclear pore structure facilitates important cellular functions including regulation and signaling.
Biological function summary
The organization and function of the nuclear pore complex involve NUP43 integration. It forms part of a larger supramolecular structure assisting in functions alongside other nucleoporins. Inside the NPC NUP43 contributes to nuclear-cytoplasmic transport by interacting with transport receptors and cargo molecules. This interaction regulates the entry and exit of macromolecules maintaining cellular homeostasis and gene expression processes.
Pathways
NUP43 integrates cellular pathways related to nucleocytoplasmic transport and mRNA processing. It functions in tandem with other nucleoporins within the NPC such as NUP107 to control the flow of genetic information and proteins. The precise regulation through these pathways ensures cellular integrity and proper gene expression affecting a range of cellular activities essential for cell survival and adaptation.
Abnormal function or expression of NUP43 links to disorders like cancer and neurodegenerative diseases. It often associates with other nucleoporins such as NUP133 in pathologies where nuclear transport is disrupted. Understanding the role of NUP43 in these diseases contributes to insights into potential therapeutic targets which may help in the development of interventions to modulate its activity or interactions in the disease context.