Abcam, ab69650, Anti-CYP2S1 antibody

Size: 100µg
Rabbit Polyclonal CYP2S1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CYP2S1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CYP2S1. The exact immunogen used to generate this antibody is proprietary information.Q96SQ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab69650 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2S1 also known as Cytochrome P450 2S1 is a member of the cytochrome P450 superfamily of enzymes. This protein has a molecular weight of approximately 56 kDa. It is mainly expressed in extrahepatic tissues with high presence noted in the liver lungs and small intestine. Its expression is also observable in epithelial tissues and certain tumor types. The function of CYP2S1 involves oxidation reactions particularly those linked to fatty acids and xenobiotic metabolism.
Biological function summary
CYP2S1 plays an essential role in drug metabolism and the detoxification of chemicals. It participates in the processing of endogenous and exogenous compounds and operates alongside other members of the cytochrome P450 family. While CYP2S1 is not part of a conventional multi-protein complex its interactions with other proteins in the family influence its activity. Its reductase partners assist in electron transfer required for enzyme functionality.
Pathways
CYP2S1 is involved in pathways associated with xenobiotic metabolism and the degradation of specific fatty acids. It functions in these pathways by acting on substrates introduced by diet or environmental exposure. CYP1A1 and CYP2B6 are other cytochrome P450 enzymes that share interactions with CYP2S1 influencing shared metabolic and signaling pathways. This cooperation provides metabolism versatility and regulates substrate-specific detoxification.
CYP2S1 has connections to cancer and inflammatory conditions. It is especially relevant in the context of lung and breast cancer where altered expression levels are often observed. The enzymes CYP2E1 and CYP1A2 also participate in cancer-related processes due to their roles in the activation of pro-carcinogens. In inflammatory diseases the activity of CYP2S1 influences lipid mediator levels which can contribute to disease progression or suppression.