Abcam, ab69860, Anti-RIM2 antibody

Size: 100µg
Rabbit Polyclonal RIM2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RIMS2. The exact immunogen used to generate this antibody is proprietary information.Q9UQ26,
Specificity:RIM2 is known to exist in multiple isoforms; this antibody should recognize most of them. The antibody is predicted to have no cross reactivity to other RIM proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIM2 also known as Rab3-interacting molecule 2 is a protein that facilitates synaptic vesicle priming. It acts as an important component in the release of neurotransmitters at synaptic junctions. The RIM2 protein has a molecular weight of approximately 150 kDa. Researchers often find it expressed in neuronal tissues where it plays an important role in neurotransmitter release.
Biological function summary
RIM2 interacts with other proteins to form a complex that stabilizes synaptic transmission. This protein complex is essential for the regulation of neurotransmitter release maintaining synaptic vesicle docking and priming processes. RIM2 facilitates a balance in the presynaptic terminal influencing the effective throughput of signals between neurons. Its precise location in nerve cells allows it to function efficiently in the rapid and controlled release of neurotransmitters.
Pathways
RIM2 plays a critical role in the regulation of the synaptic vesicle cycle and neurotransmitter release pathways. It often interacts with proteins such as Munc13 and synaptotagmin which are important in the synaptic vesicle fusion process. Through this involvement RIM2 contributes to the proper function of synaptic signaling and communication within the nervous system.
Studies link RIM2 dysregulation to neurological disorders like epilepsy and autism spectrum disorder. The disruption of its interaction with proteins such as Rab3 can lead to impaired synaptic function and subsequent neurological symptoms. Understanding RIM2's role offers insights into therapeutic approaches for treating associated neurological disorders.