Abcam, ab70112, Anti-COX4I2 antibody

Size: 100µg
Rabbit Polyclonal COX42 antibody. Suitable for WB, ICC/IF and reacts with Human, African green monkey samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human COX4I2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human COX4I2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q96KJ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70112 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The COX4I2 also known as cytochrome c oxidase subunit 4 isoform 2 is a protein that plays an important role in the electron transport chain in mitochondria. It has a molecular mass of approximately 19 kDa. COX4I2 is expressed in mitochondrial membranes and is particularly found in tissues with high oxygen demand like the heart and skeletal muscles. Unlike its close relative COX4I1 COX4I2 is expressed variably depending on the oxygen availability in the tissues where it functions.
Biological function summary
COX4I2 contributes to cellular energy production by being part of the cytochrome c oxidase complex also known as complex IV of the electron transport chain. This complex is central in the final step of electron transfer during cellular respiration facilitating the reduction of oxygen to water. By doing so it aids in establishing the proton gradient that drives ATP synthesis. Its expression adjusts according to oxygen levels which suggests a responsive role in adapting cellular metabolism to hypoxic conditions.
Pathways
COX4I2 is integrally involved in the oxidative phosphorylation pathway. In this pathway it collaborates with other complex IV subunits to influence the respiratory chain efficiency and energy production. COX4I2 works alongside other proteins like COX1 and COX2 ensuring effective electron transfer and proton pumping. Additionally it has connections to the hypoxia-inducible factor (HIF) pathway influencing how cells respond to low oxygen conditions.
COX4I2 has links to conditions like cancer and mitochondrial disorders. Hypoxia a common feature in tumor microenvironments often leads to increased COX4I2 expression adapting the cancer cell metabolism to survive low oxygen. In mitochondrial disorders improper function or regulation of COX4I2 can impair ATP production leading to symptoms in high energy-demand tissue. COX4I2 might interact with other mitochondrial proteins such as COX4I1 in these scenarios affecting the overall function of the respiratory chain in pathological states.