Abcam, ab70114, Anti-AL-1 antibody

Size: 100µg
Rabbit Polyclonal AL-1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human EFNA5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EFNA5. The exact immunogen used to generate this antibody is proprietary information.P52803

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70114 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AL-1 also known as Anxa1 is a protein that plays a role in immune response and inflammation. It weighs approximately 38 kDa and can be found inside various tissues especially in immune cells like neutrophils and macrophages. Researchers often use animal models particularly in mouse studies to examine AL-1 functions due to its significance in biological processes.
Biological function summary
The protein acts as a modulator in both innate and adaptive immune systems helping in the resolution of inflammation. AL-1 may function as part of a complex in these processes interacting with receptors on the cell surface. This protein regulates actions including cell migration and apoptotic cell clearance directly impacting how the body responds to infection and inflammation.
Pathways
AL-1 influences key immunological processes via the phospholipase A2-inhibitory pathway. It can interact with proteins like S100A11 playing an important role in feedback mechanisms that control inflammation levels. AL-1 also interfaces with the annexin pathway which is important for modulating cell membrane interactions during immune responses.
AL-1 is linked with inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. In these conditions researchers found that altered AL-1 expression affects the inflammation resolution process. Connections have been made to related proteins like integrins which can modulate AL-1 activity in immune responses highlighting its potential as a therapeutic target for managing chronic inflammation.