Abcam, ab70184, Anti-DDX17 antibody

Size: 100µL
Rabbit Polyclonal DDX17 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human DDX17.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DDX17. The exact immunogen used to generate this antibody is proprietary information.Q92841

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70184 was affinity purified using an epitope specific to DDX17 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDX17 also known as RNA helicase p72 is an enzyme that unwinds RNA molecules. It belongs to the DEAD-box protein family. Its mechanical action involves utilizing ATP to unwind RNA facilitating various RNA processing events. DDX17 weighs approximately 73 kDa making it a relatively large protein. The enzyme expresses in multiple tissues but shows substantial activity in HEK 293 cells a human embryonic kidney cell line.
Biological function summary
This enzyme plays a significant role in RNA metabolism. DDX17 is part of the spliceosome complex which is essential for splicing pre-mRNA into mature mRNA. Through its helicase activity DDX17 ensures the proper remodeling of RNA structures which is necessary for accurate splicing. The protein also contributes to the regulation of gene expression and has been observed to influence transcription factors.
Pathways
RNA processing and maturation are key biological functions of DDX17. The protein integrates into the mRNA splicing pathway where it orchestrates proper RNA folding and splice site selection. Furthermore DDX17 interacts with other DEAD-box proteins such as DDX5 to assist in chromatin remodeling and transcription regulation facilitating efficient gene expression.
Abnormal DDX17 expression or mutation links to certain cancers including breast cancer and leukemia. The protein along with DDX5 affects tumor progression by regulating pathways involved in cell proliferation. These pathways and protein interactions highlight the importance of DDX17 in maintaining normal cell function and its potential as a therapeutic target in cancer treatment.