Abcam, ab70362, Anti-ADIPOR1 antibody

Size: 100µg
Rabbit Polyclonal ADIPOR1 antibody. Suitable for WB, ICC/IF and reacts with Human, Rat, Mouse samples. Cited in 25 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adiponectin receptor 1 (ADIPOR1) is a protein that mediates the effects of adiponectin a hormone involved in glucose regulation and fatty acid breakdown. ADIPOR1 is also known as the adiponectin receptor protein 1. It has a molecular weight of approximately 42 kDa. This receptor is widely expressed in various tissues including skeletal muscle liver pancreas and adipose tissue demonstrating its broad role in metabolism.
Biological function summary
ADIPOR1 facilitates the metabolic actions of adiponectin by increasing insulin sensitivity and promoting fatty acid oxidation. The receptor does not function alone; it operates in coordination with another isoform adiponectin receptor 2 (ADIPOR2) forming a complex to exert its full biological effects. This dual receptor system supports the regulation of energy homeostasis and inflammation influencing metabolic rate and improving lipid profiles.
Pathways
ADIPOR1 plays a critical role in the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPAR-α) signaling pathway. These pathways are important for cellular energy balance and lipid metabolism. AMPK activation by ADIPOR1 leads to enhanced glucose uptake and fatty acid oxidation while interaction within the PPAR-α pathway regulates gene expression related to lipid metabolism. The activity of ADIPOR1 is intricately tied to other metabolic proteins like leptin and insulin thereby linking with these pathways.
ADIPOR1 involvement is significant in the development of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Its interaction with adiponectin and the modulation of insulin sensitivity positions it central to the pathophysiology of these conditions. These interactions highlight its potential as a therapeutic target. Disruption in ADIPOR1 function may influence related proteins such as adiponectin and insulin contributing to the progression of metabolic disorders.