Abcam, ab70386, Anti-FTSJD2 antibody

Size: 100µL
Rabbit Polyclonal FTSJD2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CMTR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CMTR1. The exact immunogen used to generate this antibody is proprietary information.Q8N1G2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FTSJD2 also known as Fatty Acid Synthase Inhibitor Domain-Containing Protein is a target expressed in a variety of human tissues. This protein has a molecular mass of approximately 60 kDa. The main function of FTSJD2 is to catalyze methylation reactions impacting RNA processing by adding methyl groups to specific adenine residues. This modification affects RNA stability and function playing a direct role in cellular gene expression control.
Biological function summary
The FTSJD2 protein participates in RNA methylation processes and forms part of larger protein complexes involved in RNA modification. These complexes help facilitate accurate and efficient gene expression regulation across different stages of cell growth and division. The participation of FTSJD2 in these complexes emphasizes its role in modulating many cellular activities that depend on RNA methylation.
Pathways
FTSJD2 is an integral player in the RNA modification and stability pathways. These pathways are significant for cellular responses to stress and maintaining genomic integrity. FTSJD2 associates with proteins like METTL3 and ALKBH5 which assist in the dynamic control of RNA methylation. This interaction illustrates the pathway's complexity allowing cellular adaptation and robustness against various stimuli.
FTSJD2 alterations can link to cancers and neurological disorders. In oncology changes in FTSJD2 expression might disrupt normal RNA processes contributing to tumorigenesis. For neurological diseases its role in RNA processing is important for neuron function implicating FTSJD2 dysfunction in disorders like Alzheimer's disease. Studies have shown connections between FTSJD2 and proteins such as FTO in these pathological conditions suggesting avenues for therapeutic intervention.