Abcam, ab70449, Anti-DRIP130 antibody

Size: 50µL
Rabbit Polyclonal DRIP130 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MED23 aa 400-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MED23 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.Q9ULK4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DRIP130 also known as MED23 is a component of the Mediator complex. It plays a significant role as a transcriptional co-activator for RNA polymerase II transcription. DRIP130 has a molecular mass of approximately 130 kDa. Expression of DRIP130 occurs in various tissues more notably in the liver and heart indicating its widespread biological roles in the body.
Biological function summary
DRIP130 integrates signals from activators and repressors to facilitate transcription regulation. It is a part of the larger Mediator complex which is essential for conveying instructions from transcription factors to RNA polymerase II. By acting at promoters DRIP130 helps modulate gene expression impacting processes like cell growth and differentiation. Its function within this multi-subunit complex emphasizes its importance in cellular communication and transcriptional regulation.
Pathways
DRIP130 contributes to the MAPK/ERK signaling pathway and the Wnt signaling pathway. Within these pathways it interacts with proteins such as MAPK and β-catenin to influence cell cycle progression and cellular responses. These pathways are critical for controlling growth and maintaining cellular functions indicating DRIP130's vital role in pathway integration and cellular homeostasis.
DRIP130 has connections to cancer and neurological disorders. Alterations in DRIP130 expression or function can lead to aberrant cell proliferation contributing to cancer development. Moreover DRIP130's interaction with proteins like β-catenin in the Wnt pathway may influence neurological conditions by affecting neural cell signaling or development. Understanding these links provides insight into potential therapeutic targets for managing such disorders.