Abcam, ab70545, Anti-IGBP1 antibody

Size: 100µL
Rabbit Polyclonal IGBP1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IGBP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IGBP1. The exact immunogen used to generate this antibody is proprietary information.P78318

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Insulin-like Growth Factor Binding Protein 1 (IGBP1) is a multifunctional protein involved in various cellular processes. It is also known as IGFBP-1 and has a molecular mass of approximately 31 kDa. IGBP1 is widely expressed in human tissues with higher levels detected in the liver and the endometrium. The protein plays a role in modulating the availability of insulin-like growth factors (IGFs) by binding to them affecting their function and stability within the body.
Biological function summary
Many cellular processes involve IGBP1 as it binds with insulin-like growth factors to modulate their actions effectively acting as a regulator within the IGF system. IGBP1 may influence cell growth survival and metabolism. It often interacts with other proteins within an IGF-binding complex allowing it to perform various regulatory functions that impact both normal and pathological conditions.
Pathways
Several signaling pathways incorporate the activities of IGBP1 particularly the insulin-like growth factor signaling pathway and the PI3K/AKT pathway. IGBP1 interacts with other proteins such as IGF1R and IRS-1 affecting downstream signaling that governs aspects of cell proliferation and survival. These interactions position IGBP1 as an important regulatory molecule in these pathways influencing cellular responses to IGFs.
Research has linked abnormal levels or activities of IGBP1 with conditions such as diabetes and cancer. IGBP1's modulation of the insulin-like growth factors may affect insulin sensitivity and glucose metabolism contributing to diabetes pathogenesis. In cancer altered IGBP1 expression can influence tumor growth and progression where its relationship with IGF1 and IGF2 is significant in the context of growth factors and their signaling pathways.