Abcam, ab70564, Anti-CoCoA antibody

Size: 100µL
Rabbit Polyclonal CoCoA antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CALCOCO1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CALCOCO1. The exact immunogen used to generate this antibody is proprietary information.Q9P1Z2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70564 was affinity purified using an epitope specific to CoCoA immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CoCoA also known as CCNDBP1 or Coactivator of Coactivator is a protein with a molecular mass of approximately 65 kDa. It acts as a transcription coactivator and interacts with other transcription factors to enhance gene expression. CoCoA is widely expressed in a variety of tissues suggesting a broad role in cellular processes. The protein’s expression in diverse cell types highlights its involvement in fundamental biological activities.
Biological function summary
CoCoA plays a significant role in the transcriptional regulation of genes. It functions as a part of multiprotein complexes where it assists in the enhancement of transcriptional activity by interacting with nuclear receptors and other coactivators. This interaction and formation of complexes allow CoCoA to efficiently fine-tune gene expression facilitating cell proliferation differentiation and various cellular responses. Its ability to modulate transcription makes CoCoA an important player in controlling the cell cycle and other vital cellular processes.
Pathways
Numerous cellular processes such as steroid hormone signaling and Wnt signaling pathways involve CoCoA. These pathways play a critical role in regulating developmental and physiological processes. CoCoA interacts with the estrogen receptor impacting the steroid hormone signaling pathway and it also ties with β-catenin in the Wnt signaling pathway. These interactions enable CoCoA to coordinate the transcription of specific target genes necessary for cellular development and homeostasis.
CoCoA has connections to cancer and neurodegenerative diseases. In the context of cancer altered CoCoA expression or function can influence tumor progression with changes linked to breast and prostate cancers. In these situations CoCoA affects pathways with proteins like estrogen receptor or androgen receptor. Regarding neurodegenerative diseases CoCoA may contribute through its regulatory roles in signaling pathways that include interactions with proteins known for neural function. Understanding CoCoA's role across these diseases may unveil potential therapeutic targets.