Abcam, ab70627, Anti-ASC1 antibody

Size: 100µL
Rabbit Polyclonal ASC1 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human TRIP4 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRIP4 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q15650

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ASC1 protein also known as ASC-1 is a multifunctional protein involved in several cellular processes. It has a mass of approximately 41 kDa and is primarily expressed in the nucleus of cells. Some studies highlight its presence in diverse tissues indicating a potential broad involvement in different cellular activities. While the protein itself is known common names like ASCONE procedure refer to specialized contexts or nomenclature systems related to ASC1.
Biological function summary
ASC1 plays a significant role in the regulation of transcription and acts as a coactivator of nuclear receptors. It forms part of a larger transcription regulatory complex partnering with other coactivators and transcriptional machinery to enhance gene expression. Its interaction capacity signifies its importance in modulating gene expression patterns thereby affecting cellular physiology at the transcriptional regulation level.
Pathways
ASC1 engages primarily with the nuclear receptor signaling pathways and transcription regulation pathways. Within these pathways it interacts with other proteins like steroid receptor coactivators to modulate various responses to hormonal signals. This integration into complex pathways highlights ASC1's importance in maintaining cellular homeostasis and response to external signals.
ASC1 is linked to cancers particularly hormone-responsive cancers like breast and prostate cancer. Its interaction with nuclear receptors like estrogen receptor and androgen receptor connects ASC1 to the regulation of these cancers' progression. Moreover mutations or dysregulation of ASC1 can contribute to the aberrant expression of genes that promote tumorigenicity. Understanding ASC1 interactions with other coactivators can provide insight into potential therapeutic targets for these cancers.