Abcam, ab70744, Anti-HURP antibody

Size: 100µL
Rabbit Polyclonal HURP antibody. Suitable for IP, WB and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human DLGAP5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DLGAP5. The exact immunogen used to generate this antibody is proprietary information.Q15398

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HURP also known as Hepatoma Up-Regulated Protein is a protein involved in spindle formation during cell division. It has an approximate mass of 82 kilodaltons. The expression of HURP is notably high in the liver and is also present in various other tissues. It performs essential mechanical roles in stabilizing microtubules which are necessary for accurate chromosome segregation during mitosis.
Biological function summary
Hepatoma Up-Regulated Protein plays an important role in the mitotic spindle assembly. As a part of the chromosomal passenger complex it works alongside other proteins to facilitate efficient cell cycle progression. HURP localizes to the mitotic microtubules and is particularly active during the metaphase of cell division contributing to correct chromosome alignment and spindle attachment.
Pathways
Hepatoma Up-Regulated Protein functions within the cell cycle regulation pathway especially influencing mitotic processes. The intricate network of proteins it associates with includes Aurora kinase B and Ran GTPase which are essential for mitotic checkpoint control and spindle assembly. HURP helps maintain chromosomal stability which is important for preventing genetic aberrations.
Hepatoma Up-Regulated Protein has links to several cancer types including liver cancer. HURP overexpression often correlates with tumor progression and poor prognosis. It interacts with proteins like Aurora kinase B which is also implicated in oncogenesis suggesting that HURP may serve as a potential biomarker or therapeutic target in cancer research.