Abcam, ab70795, Anti-TIPRL antibody

Size: 100µL
Rabbit Polyclonal TIPRL antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TIPRL.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TIPRL. The exact immunogen used to generate this antibody is proprietary information.O75663

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70795 was affinity purified using an epitope specific to TIPRL immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIPRL also known as TIP41-like protein weighs approximately 39 kDa. It functions by interacting with the alpha subunit of protein phosphatase 2A (PP2A) which acts as a negative regulator within various cellular processes. TIPRL is expressed in a variety of tissues with notable presence in the liver kidney and brain. Its modulation role occurs through binding to other proteins and influencing catalytic activities important for maintaining balance in cellular signaling.
Biological function summary
TIPRL serves a regulatory role by inhibiting phosphatase activities within the cell contributing significantly to protein dephosphorylation processes. This protein is a part of the PP2A holoenzyme complex where it serves to fine-tune its activity affecting signaling pathways that rely on phosphorylation status. Through associating with PP2A and related phosphatases TIPRL ensures proper cellular phosphoprotein turnover an important factor for healthy cellular function and response to external stimuli.
Pathways
Interaction between TIPRL and other proteins influences the mTOR signaling pathway and MAPK signaling pathways. Through these pathways TIPRL affects cellular growth proliferation and survival. TIPRL influences mTOR pathway by modulating the activity of PP2A which can affect downstream proteins like AKT and S6K1. The MAPK pathway is impacted similarly where TIPRL's interaction with PP2A alters phosphorylation state of proteins such as ERK creating implications for cell cycle progression and stress response.
TIPRL is linked to neurological disorders and certain cancers. TIPRL's regulation of pathways like mTOR and MAPK associates it with the development of glioblastomas where dysregulated signaling contributes to tumorigenesis. Additionally in neurodegenerative conditions altered TIPRL function affects phosphatase activity impacting proteins like Tau which play a role in diseases like Alzheimer's. Understanding TIPRL's modulation could provide insights into therapeutic targets for these conditions.