Abcam, ab70827, Anti-NCOA62/SNW1 antibody

Size: 100µL
Rabbit Polyclonal NCOA62/SNW1 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SNW1 aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SNW1 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.Q13573

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein NCOA62 also known as SNW1 or Ski-interacting protein functions as a transcriptional coactivator in the cell nucleus. This protein with a mass of approximately 60 kDa is involved in various transcriptional activities. You will find it expressed in many tissue types but especially in the highly proliferative ones like the liver brain and reproductive tissues. The protein associates with other nuclear receptors and transcription factors to modulate gene expression.
Biological function summary
NCOA62/SNW1 interacts with several transcription complexes playing an important role in modulating transcriptional signals. It acts as a scaffolding molecule facilitating the assembly and function of specific transcriptional complexes. It binds with various partners including the Smad and p53 proteins partaking in cell cycle regulation and DNA repair processes. Its role in transcription complex suggests its involvement in essential cellular functions.
Pathways
NCOA62/SNW1 plays a role in the TGF-beta signaling pathway and the p53 pathway. These pathways are critical for regulating cell growth differentiation and apoptosis. Within the TGF-beta pathway the protein aids in transmitting signals from the cell membrane to the nucleus by interacting with Smad proteins. It also influences the p53 pathway by modulating p53 activity an important protein recognized for its role in maintaining genomic integrity and responding to cellular stress.
NCOA62/SNW1 displays significant involvement in several medical conditions including cancer and neurodegenerative diseases. In cancer it influences the cell cycle and apoptosis by interacting with Smad and p53 potentially leading to uncontrolled cell growth when dysregulated. Regarding neurodegenerative disorders alterations in NCOA62/SNW1 expression or function could contribute to neuronal cell death by disrupting normal cell signaling mechanisms connected possibly through interaction with p53 well-known for its involvement in cell death and survival pathways.