Abcam, ab70841, Anti-FIGNL1 antibody

Size: 100µL
Rabbit Polyclonal FIGNL1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FIGNL1 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FIGNL1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q6PIW4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FIGNL1 (Fidgetin-Like 1) is a member of ATPase family associated with various cellular processes. It bears a molecular mass of approximately 80 kDa. This protein showcases a unique functionality due to its capacity for microtubule severing and remodeling activities. FIGNL1 performs a role in regulating cytoskeletal dynamics which are critical during key cellular events. The expression of FIGNL1 occurs in various tissues with significant expression levels observed in the testes and ovary emphasizing its importance in reproduction.
Biological function summary
FIGNL1 functions in DNA repair and homologous recombination processes. It becomes part of a larger protein complex facilitating its involvement in maintaining genomic integrity. This connection to DNA repair pathways demonstrates its essential role in preventing genotoxic stress. FIGNL1 interacts with proteins such as RAD51 aiding in the accurate repair of DNA double-strand breaks which prevents the accumulation of potentially harmful genetic errors.
Pathways
FIGNL1 integrates into the DNA damage response and repair pathways. It plays an important part in the homologous recombination repair pathway ensuring chromosome stability during cell division. Related proteins like BRCA2 influence FIGNL1’s function within this pathway linking it to mechanisms that preserve cellular genomic stability. The presence of these interactions is significant for a well-functioning cellular response to DNA damage.
FIGNL1's malfunction or inadequacy may contribute to cancer and infertility issues. Research indicates its association with breast cancer in which its pathway partners like BRCA2 become pivotal for understanding tumorigenesis. Additionally disruptions in its regulation can cause infertility highlighting its necessity in reproductive health. Through these pathways FIGNL1 connects to broader clinical concerns suggesting that its proper expression and function are critical for preventing disease.