Abcam, ab71152, Anti-SIN1 antibody

Size: 100µL
Rabbit Polyclonal SIN1 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human MAPKAP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAPKAP1. The exact immunogen used to generate this antibody is proprietary information.Q9BPZ7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SIN1 also known as MAPKAP1 or mTORC2 component is a protein with a mass of approximately 66 kDa. It is an essential part of the mTOR complex 2 (mTORC2) a component critical for controlling cell growth and metabolism. SIN1 is expressed in various tissues indicating its broad role in numerous cellular processes. This expression includes key sites like the liver heart and muscle tissues.
Biological function summary
SIN1 plays an important role in regulating mTORC2 which participates in the phosphorylation of Akt (Protein Kinase B). It forms part of the mTORC2 complex along with mTOR (mechanistic target of rapamycin) and RICTOR (Rapamycin-Insensitive Companion of mTOR). This complex influences cytoskeletal organization cell survival and nutrient sensing important for many cellular functions.
Pathways
SIN1 involvement in mTOR signaling and PI3K-Akt pathways highlights its significance. These pathways are vital for cell growth proliferation and survival. Through mTORC2 it regulates Akt phosphorylation impacting downstream processes including processes controlled by proteins like SGK (serum and glucocorticoid-regulated kinase). SIN1's interactions within these pathways highlight its central role in cell signaling networks.
SIN1 shows links to cancer and diabetes pointing to its influence in disease progression. Alterations in the mTOR signaling pathway involving SIN1 can lead to dysregulated cell growth common in cancerous states. In diabetes the mTOR pathway combined with proteins like insulin receptors affects insulin signaling and glucose homeostasis making SIN1 a target of interest for therapeutic research.