Abcam, ab71977, Anti-CCNB1IP1 antibody

Size: 50µg
Mouse Polyclonal CCNB1IP1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCNB1IP1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CCNB1IP1.Q9NPC3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCNB1IP1 also known as HEI10 is a protein that functions mechanically as an E3 ubiquitin-protein ligase. It plays a role in tagging proteins for degradation. This protein weighs approximately 28 kDa. CCNB1IP1 is mainly expressed in the testis indicating its importance in reproductive organ function. The regulation and activity of CCNB1IP1 are critical in the control of cellular processes particularly those related to cell cycle progression.
Biological function summary
The protein CCNB1IP1 is involved in homologous recombination during meiosis. It is a part of a complex that includes proteins responsible for the repair and reorganization of DNA strands. Its activity ensures accurate chromosome segregation and genetic diversity during the formation of gametes. The presence of CCNB1IP1 in this recombination complex underlines its role in maintaining genomic stability.
Pathways
CCNB1IP1 participates in the DNA Damage Response pathway which is essential for detecting and repairing DNA lesions. It is also involved in the meiotic recombination checkpoint pathway ensuring accurate cell division. During these pathways CCNB1IP1 interacts with several other proteins such as RAD51 and DMC1 critical to DNA strand exchange and repair. These interactions position CCNB1IP1 as a central player in maintaining cell integrity during meiosis.
Mutations or dysregulation of CCNB1IP1 are linked to reproductive disorders particularly male infertility due to disrupted meiotic recombination. CCNB1IP1 is also studied in relation to certain cancers as defects in meiotic processes can result in genomic instability observed in tumorigenesis. The relationship between CCNB1IP1 mutations and these conditions often involves other proteins like BRCA2 which plays a role in homologous recombination repair highlighting potential shared genetic pathways in disease mechanisms.