Abcam, ab72115, Anti-WDR33 antibody

Size: 100µL
Rabbit Polyclonal WDR33 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human WDR33.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human WDR33. The exact immunogen used to generate this antibody is proprietary information.Q9C0J8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab72115 was affinity purified using an epitope specific to WDR33 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR33 also known as WD repeat domain 33 is a protein that plays an important role in transcription and RNA processing. It weighs approximately 150 kDa. WDR33 is expressed in various tissues including the heart lung and neurons indicating its broad functional relevance across different biological systems. As part of the cellular machinery it functions in transcription regulation and RNA processing by interacting with other components of these systems.
Biological function summary
The function of WDR33 extends to involvement in the cleavage and polyadenylation specificity factor (CPSF) complex. This complex is responsible for the processing of pre-mRNA specifically in mediating 3' end formation through cleavage and polyadenylation. Such activity is important for gene expression regulation highlighting WDR33's significant role in cellular gene expression controls. The protein interactions within the CPSF complex enable precise regulation of mRNA influencing protein synthesis.
Pathways
WDR33 interacts within the polyadenylation pathway and contributes to RNA maturation and stability. It partners with other vital proteins like CPSF1 and CPSF3 playing a part in the polyadenylation signal recognition. This process is important for RNA stability and subsequent translation into functional proteins. Additionally WDR33 is involved in transcription termination linking it to foundational cellular processes necessary for proper genetic expression.
WDR33 has been linked to developmental and neurological conditions. Mutations affecting WDR33 or alterations in its associated pathways can result in genetic disorders impacting developmental processes. Furthermore its interaction with components like CPSF2 in pathways can influence neurological functions where dysregulation may contribute to neurodegenerative diseases. These associations underline WDR33 as a focal point in understanding certain pathologies and potential therapeutic interventions.