Abcam, ab72118, Anti-PIBF antibody

Size: 100µL
Rabbit Polyclonal PIBF antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PIBF1 aa 700 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PIBF1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8WXW3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab72118 was affinity purified using an epitope specific to PIBF immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The progesterone-induced blocking factor (PIBF) is a protein with a molecular mass of approximately 90 kDa. It has important roles linked to cell division and immune response regulation. PIBF is produced in larger quantities in pregnancy tissues particularly by decidual and trophoblastic cells but normal lymphocytes also express it when stimulated by progesterone. Researchers often study its activity because of its potential relevance in pregnancy and immune system interactions.
Biological function summary
Researchers already documented that PIBF plays a role in modulating immune responses during pregnancy. It acts as part of a complex involving progesterone and cytokines working to prevent the mother's immune system from rejecting the fetus. PIBF achieves this by influencing the Th1/Th2 cytokine balance increasing anti-inflammatory cytokines and decreasing pro-inflammatory cytokines like IL-6 and IL-12. This helps to maintain a tolerogenic environment during pregnancy.
Pathways
The PIBF significantly affects pathways involving immune regulation and inflammation. It interacts with the hormonal pathway of progesterone linking it to the immune-modulatory functions controlled by cytokine action. The balance between these pathways ensures immune tolerance in the placenta. PIBF also shares a functional pathway with proteins such as interleukin-10 (IL-10) as they both modulate immune responses to support successful pregnancies.
PIBF has significant associations with pregnancy-related conditions and certain cancers. Abnormal PIBF levels may relate to pregnancy complications such as recurrent spontaneous abortion where immune tolerance gets disrupted. Additionally PIBF can impact tumor growth because it promotes an immunosuppressive environment similar to that observed in pregnancy potentially benefiting malignant cells. This connection suggests that PIBF along with related proteins like IL-10 could serve as a target for therapeutic interventions in these conditions.