Abcam, ab72233, Anti-HMGN3 antibody

Size: 100µL
Rabbit Polyclonal HMGN3 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HMGN3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HMGN3. The exact immunogen used to generate this antibody is proprietary information.Q15651

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HMGN3 also known as High Mobility Group Nucleosome-Binding Domain 3 is a protein that interacts with chromatin and influences its structure. It weighs approximately 10 kDa. HMGN3 is expressed in various tissues with high levels found in the brain pancreas and kidney. This protein regulates chromatin compaction impacting gene expression and cellular functions.
Biological function summary
HMGN3 functions by modulating the access of transcription factors to DNA. It is not a part of any known multi-protein complex but acts independently. By altering the chromatin landscape HMGN3 plays a role in the regulation of genes involved in metabolism and neurodevelopment impacting cellular processes like energy balance and synaptic function.
Pathways
HMGN3 participates in the insulin signaling and neurodevelopmental pathways. It influences the insulin signaling pathway by affecting genes that manage glucose metabolism. Related proteins include insulin receptor substrate 1 (IRS1) as they work together to ensure proper metabolic responses. In the neurodevelopmental context HMGN3 interacts with pathways involving the brain-derived neurotrophic factor (BDNF) contributing to the development and plasticity of neurons.
HMGN3 relates to type 2 diabetes and neurodegenerative diseases like Alzheimer's. The role of HMGN3 in glucose metabolism links it to type 2 diabetes alongside proteins like IRS1 that influence insulin resistance. In Alzheimer's disease HMGN3 might contribute to synaptic dysfunction interacting with BDNF and other neurotrophic factors signaling potential areas of therapeutic interest.