Abcam, ab72234, Anti-TRIM47 antibody

Size: 100µL
Rabbit Polyclonal TRIM47 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM47.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRIM47. The exact immunogen used to generate this antibody is proprietary information.Q96LD4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM47 also known as Tripartite Motif Containing 47 or GOF functions as an E3 ubiquitin ligase. This protein has a molecular mass of approximately 67 kDa. It participates in the process of transferring ubiquitin from E2 conjugating enzyme to substrate proteins which leads to proteasomal degradation of these proteins. TRIM47 is expressed in various tissues with high levels observed in the testis and brain and it shows differential expression in certain types of cancers.
Biological function summary
TRIM47 affects cellular processes by regulating protein stability and turnover. As an E3 ubiquitin ligase it assists in tagging proteins for degradation which is important for maintaining protein homeostasis within the cell. By controlling protein levels TRIM47 influences cellular proliferation differentiation and apoptosis. It is involved in the degradation of proteins that are part of cellular signaling pathways which can impact the cell's response to external stimuli and stress.
Pathways
Multiple cellular responses and regulatory networks are influenced by TRIM47 activity. It plays a role in the ubiquitin-proteasome pathway and is involved in the regulation of NF-kB signaling pathways. This interconnection guides how cells react during inflammation and immune responses. TRIM47 interacts with proteins such as IκBα which further allows it to modulate the NF-kB pathway therefore indirectly affecting genes involved in inflammation and immune cell survival.
TRIM47 expression levels correlate with certain cancers including glioblastoma and breast cancer. Dysregulation of TRIM47 can lead to increased degradation of tumor-suppressor proteins promoting tumor growth and progression. The protein's role in cancer links it to other proteins involved in cancer pathways such as p53 and PTEN which are known for their functions in regulating cell cycle and apoptosis. Understanding TRIM47's interactions with these proteins can reveal new therapeutic targets for cancer treatment.