Abcam, ab72660, Anti-METTL11A antibody

Size: 50µg
Mouse Polyclonal METTL11A antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NTMT1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NTMT1.Q9BV86

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
METTL11A also known as PCMT1 or methyltransferase-like protein 11A functions mechanically as a protein methyltransferase specifically responsible for the methylation of the N-terminal alpha-amino group on proteins. This methylation process affects the function and stability of target proteins. METTL11A exhibits a molecular mass of approximately 32 kDa. It is widely expressed in human tissues particularly in the liver and brain indicating its important role in different physiological contexts.
Biological function summary
The enzyme influences protein interactions by modifying proteins at the molecular level impacting their stability and function. METTL11A contributes to various processes including protein repair and turnover mechanisms. It may operate independently or within larger protein complexes though further research is necessary to identify specific complex partners. This enzymatic activity is fundamental for maintaining protein homeostasis and ensuring proper cellular function.
Pathways
METTL11A engages in the protein methylation pathway which is vital for regulating protein function and interactions. This pathway often involves other key proteins such as PCMT1 that work together to methylate proteins and modify their activities. Additionally METTL11A plays a significant role in the protein repair pathway where it repairs damaged proteins assisting in the prevention of cellular stress and damage.
METTL11A could have implications in neurological disorders like Alzheimer's disease. Alzheimer's has been linked to disrupted protein metabolism where the absence or malfunction of METTL11A activity affects protein stability and accumulation. Furthermore METTL11A's interactions with proteins such as PCMT1 might complicate the protein methylation processes potentially contributing to liver disease by disrupting normal cellular protein functions in the liver emphasizing the importance of METTL11A in disease contexts.