Abcam, ab7318, Anti-Spermidine antibody

Size: 200µL
Rabbit Polyclonal Spermidine antibody. Suitable for IHC-P and reacts with Chemical samples. Cited in 9 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Spermidine.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Reacts with spermidine and cross reacts with spermine.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Spermidine also known as SPD is a polyamine with a molecular mass of approximately 145.25 g/mol. It originates from the decarboxylation product of putrescine and is synthesized in the cytoplasm. Spermidine expresses ubiquitously in both prokaryotic and eukaryotic cells. Its mechanical role involves stabilizing the structure of the ribosome and enhancing nucleic acid functions. Through its interaction with RNA it influences cellular functions like growth and proliferation.
Biological function summary
This polyamine plays an important role in cellular processes such as autophagy where it acts as an important regulator. Spermidine is not part of a larger protein complex but it interacts directly with other cellular components to modulate cellular homeostasis and stress resistance. Additionally spermidine is involved in processes like telomerase activity and apoptosis proving its significance in cell maintenance and longevity.
Pathways
Spermidine significantly contributes to the polyamine biosynthesis and catabolism pathways. It is involved in the regulation of the mechanistic target of rapamycin (mTOR) pathway which is important for controlling cellular growth and metabolism. Spermidine functions in connection with proteins like ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) which are pivotal for the polyamine synthesis pathway and interconnected processes.
Spermidine shows relevance to conditions such as neurodegenerative disorders and certain cancers. Its ability to modulate autophagy suggests its importance in mitigating the progression of neurodegenerative diseases like Alzheimer's. Additionally spermidine's role in cell growth regulation links it to cancer as dysregulated polyamine metabolism often correlates with tumorigenesis. In these conditions spermidine interacts with proteins such as Beclin 1 in autophagy and MYC in cell growth regulation highlighting its therapeutic potential in managing these diseases.