Abcam, ab7349, Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker

Size: 100µg / 1mg
Anti-Myelin Basic Protein antibody [12] (ab7349) is a rat monoclonal antibody detecting Myelin Basic Protein in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Clone 12 is the most cited clone to Myelin Basic Protein - Over 310 publications - Trusted since 2001
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:12,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Epitope:Amino acids 82-87 (DENPVV).

Product details:
Anti-Myelin Basic Protein antibody [12] (ab7349) is a rat recombinant monoclonal antibody and is validated for use in ICC/IF, IHC-P and WB.
Anti-Myelin Basic Protein antibody [12] (ab7349) was first used in a scientific publication in 1987 and has been cited over 310 times in peer reviewed journals. It's performance in Western blot, immunofluorescence and IHC in mouse samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-Myelin Basic Protein antibody [12] (ab7349) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Myelin Basic Protein antibody [12] (ab7349) has 22 independent reviews from customers.
Anti-Myelin Basic Protein antibody [12] (ab7349) specifically detects Myelin Basic Protein (UniProt ID: P02686; Molecular weight: 34kDa) and is sold in 100 ug and 1 mg selling sizes.
Conjugation-ready, carrier free format available for antibody clone 12 -
ab277483
Myelin Basic Protein (MBP) is a critical protein in neuro research, particularly for its role in the formation and maintenance of the myelin sheath. This sheath insulates nerve fibers, significantly increasing the speed of electrical signal transmission. Researchers use MBP to study myelination processes and demyelinating diseases such as multiple sclerosis, making it essential for understanding nerve function and pathology in various neurological conditions. Its expression helps in assessing the integrity and repair of myelin in the central nervous system.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.
Biological function summary
MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.
Pathways
MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.
MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.