Abcam, ab73548, Anti-WDR36 antibody

Size: 200µL
Rabbit Polyclonal WDR36 antibody. Suitable for WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human WDR36.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-Fr, IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human WDR36. The exact immunogen used to generate this antibody is proprietary information.Q8NI36

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR36 also known as WD repeat domain 36 is a protein that weighs approximately 110 kDa. It contains WD repeats suggesting a role in protein-protein interactions. WDR36 is widely expressed in various tissues with notably high levels in retinal cells. Its expression pattern indicates possible involvement in multiple cellular processes especially in the eyes.
Biological function summary
WDR36 acts as a component of the ribosome biogenesis pathway. It forms part of a complex necessary for the processing of 18S ribosomal RNA a critical step in assembling the 40S ribosomal subunit. The function of WDR36 extends to ensuring proper ribosome assembly which is fundamental for protein synthesis in cells.
Pathways
WDR36 has important roles in the ribosome biogenesis and protein synthesis pathways. It interacts with other proteins such as LAS1L and NOL9 both key players in the ribosome assembly process. Through these interactions WDR36 ensures the distribution of ribosomal subunits necessary for translating mRNA into functional proteins.
Mutations in WDR36 have links to primary open-angle glaucoma. This condition leads to progressive optic nerve damage affecting vision. WDR36's interaction with proteins like OPTN hints at a broader role in ocular health possibly influencing cellular stress responses and apoptotic pathways within the eye tissues.