Abcam, ab74045, Anti-CEBPG antibody

Size: 100µg
Rabbit Polyclonal CEBPG antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CEBPG.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CEBPG. The exact immunogen used to generate this antibody is proprietary information.P53567

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CCAAT/enhancer-binding protein gamma (CEBPG) also known as C/EBPγ is a transcription factor that regulates gene expression by binding to DNA. It weighs approximately 18-19 kDa. CEBPG is expressed in various tissues including liver lung and adipose tissue. This broad expression pattern suggests CEBPG interacts with cellular processes across different physiological contexts.
Biological function summary
CEBPG serves as a regulator of cellular differentiation and proliferation. It often forms dimers with other C/EBP family members enhancing its DNA binding capacity and functional diversity. By participating in these complexes CEBPG helps maintain homeostasis and regulate immune responses. Its activity is vital for controlling genes involved in metabolism and inflammation.
Pathways
CEBPG functions within the MAPK signaling pathway and the IL-6 signaling pathway. In the MAPK pathway it interacts with proteins such as JNK thereby influencing cell growth and apoptosis. In the IL-6 pathway CEBPG contributes to the modulation of the inflammatory response. This involvement makes CEBPG a significant player in immune function and cellular stress responses.
CEBPG has relevance to conditions like leukemia and chronic inflammatory diseases. Alterations in CEBPG expression or function can disrupt normal cell cycle control linking it to oncogenesis. In leukemia CEBPG interacts with proteins such as CEBPA influencing hematopoietic stem cell differentiation. In chronic inflammatory diseases CEBPG’s role in regulating inflammatory pathways can exacerbate or mitigate disease symptoms.