Abcam, ab74531, Anti-STELLAR antibody

Size: 100µg
Rabbit Polyclonal STELLAR antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DPPA3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DPPA3. The exact immunogen used to generate this antibody is proprietary information.Q6W0C5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STELLAR also known as 'STELLA' or 'DPPA2' acts mechanically as a regulator of pluripotency and early embryonic development. It weighs approximately 17 kDa. This protein expresses itself in pluripotent stem cells and germ cells. Researchers have found subcellular localization of STELLAR mainly in the nucleus suggesting critical functions in gene regulation during cell differentiation.
Biological function summary
The protein plays an important role in maintaining cell totipotency and germ cell specification. STELLAR interacts with several cellular complexes that are pivotal during embryogenesis. By regulating specific genes STELLAR contributes to the repression of inappropriate gene expression in pluripotent cells impacting cellular fate outcomes during development.
Pathways
STELLAR participates in the pluripotency regulatory network involving significant pathways like the Wnt signaling pathway. This protein's regulatory mechanisms align with other transcription factors such as NANOG and OCT4 highlighting its role in the maintenance of the pluripotent state. The interplay among these factors establishes a complex circuit essential for the retention of stem cell properties.
Aberrant expression or regulation of STELLAR associates with certain cancers. Its connection to disorders like germ cell tumors suggests an oncogenic potential when dysregulated. Moreover STELLAR's interaction with proteins such as LIN28 highlights its involvement in tumorigenic processes shedding light on its significance in both normal development and pathological states.