Abcam, ab74560, Recombinant Mumps virus wild-type, Gloucester strain, nucleocapsid protein

Size: 100µg
Recombinant Mumps virus wild-type, Gloucester strain, nucleocapsid protein is a Mumps virus Miyahara vaccine Full Length protein, expressed in Saccharomyces cerevisiae , with >95%, suitable for ELISA, WB, SDS-PAGE.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Saccharomyces cerevisiae,
Tags:Tag free,
Applications:WB, SDS-PAGE, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P21186,
Animal free:No,
Carrier free:No,
Species:Mumps virus Miyahara vaccine,
Reconstitution:Reconstitute in water, 50% glycerol,
Storage buffer:Constituents: PBS

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Reconstitute for long term storage

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Mumps virus wild-type Gloucester strain nucleocapsid protein plays an important role in the encapsidation of the viral RNA genome which facilitates the replication process of the virus. This protein also known as NP has a mass of approximately 57 kDa and expresses itself in infected host cells where it forms a nucleocapsid structure. The nucleocapsid protein interacts tightly with viral RNA protecting it from host nucleases and serving as a template for viral RNA synthesis.
Biological function summary
The nucleocapsid protein of the Mumps virus Gloucester strain functions as a primary structural component of the virus. It is not a part of a multi-protein complex outside of its encapsulation role although it forms oligomeric structures important for its function. By interacting with other viral proteins like phosphoprotein (P) and large protein (L) it facilitates the localization and assembly of viral components which is essential for virus replication and transcription processes.
Pathways
This nucleocapsid protein interacts directly with the virus replication and transcription machinery. It is situated within the Mumps virus life cycle pathway where it drives the replication of viral RNA. The nucleocapsid protein closely associates with the P and L proteins in these pathways enabling efficient synthesis of new viral genomes and the production of viral mRNA required for the assembly of new virions.
The nucleocapsid protein of the Mumps virus Gloucester strain is central to the pathology of mumps disease. The spread and replication of the virus within the host cells lead to systemic infections characterized by swelling of the salivary glands. There is also a risk of complications such as meningitis and encephalitis. The nucleocapsid protein's interaction with the viral P protein remains key to understanding its role in mumps-related pathogenesis.