Abcam, ab74711, Anti-RPS9 antibody

Size: 100µg
Rabbit Polyclonal RPS9 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human 40S ribosomal protein S9.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human 40S ribosomal protein S9. The exact immunogen used to generate this antibody is proprietary information.P46781

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPS9 also known as Ribosomal Protein S9 plays an important role in protein synthesis by being part of the small 40S ribosomal subunit. It has a molecular mass of approximately 22 kDa. This protein is expressed in various tissues throughout the body and is essential for ribosome function. Its primary mechanical function involves the formation of ribosomes which are key components in the translation process translating the genetic code into proteins.
Biological function summary
As a component of the ribosomal assembly RPS9 is essential for maintaining the structure and function of ribosomes. It forms a part of the ribonucleoprotein complex that ensures the fidelity and accuracy of mRNA translation during protein synthesis. This activity is vital for cell growth and proliferation as it directly influences protein production efficiency. Any disruptions in this process can lead to misfolded proteins or incomplete translations affecting cell functionality.
Pathways
The function of RPS9 is critical in the mRNA processing and translation pathways. It associates closely with other ribosomal proteins such as RPS3 and RPL11 participating in the synthesis and processing of proteins required for various cellular activities. This involvement impacts key pathways like the mTOR signaling pathway which controls cell growth and metabolism and the p53 signaling pathway which is involved in cell cycle regulation and stress responses.
The role of RPS9 implicates it in cancer and Diamond-Blackfan anemia. Mutations or dysregulation of RPS9 can lead to abnormal cell proliferation contributing to oncogenesis. RPS9 has connections with the p53 protein pathway which plays a significant role in tumorigenesis when mutated or impaired. In Diamond-Blackfan anemia defects in ribosomal protein function including that of RPS9 result in bone marrow failure and defective erythropoiesis affecting red blood cell production.