Abcam, ab75114, Anti-APOA1BP antibody

Size: 100µg
Rabbit Polyclonal APOA1BP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
APOA1BP also known as apolipoprotein A1 binding protein plays important roles in cellular lipid homeostasis and metabolism. This protein weighs approximately 28 kDa. APOA1BP is present in various tissues prominently in the mitochondria within liver and kidney cells. It displays binding affinity with apolipoprotein A1 which is an essential component of high-density lipoprotein (HDL).
Biological function summary
APOA1BP aids in stabilizing cellular processes that regulate lipid transport and cholesterol efflux. It works in close association with apolipoprotein A1 forming a functional complex that helps maintain lipid balance within cells. This interaction supports numerous cellular functions that are significant for normal metabolic activity.
Pathways
APOA1BP integrates into the reverse cholesterol transport pathway which is vital for recycling cholesterol from peripheral tissues back to the liver for excretion. It influences interactions with significant proteins such as HDL and other apolipoproteins contributing to cholesterol metabolism. Another related pathway involves lipid absorption where APOA1BP functions to facilitate efficient lipid distribution.
APOA1BP connects to cardiovascular disease due to its role in cholesterol metabolism and lipid transport. Disorders like atherosclerosis can occur when this protein's function in cholesterol efflux is impaired. Additionally APOA1BP links to inherited lipid disorders where its connection with apolipoprotein A1 and HDL becomes important in managing cholesterol levels and preventing disease progression.