Abcam, ab75674, Anti-ALDH1A2 antibody

Size: 100µg
Rabbit Polyclonal ALDH1A2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALDH1A2 also known as Retinaldehyde Dehydrogenase 2 (RALDH2) is an enzyme that plays an important role in the metabolic conversion of retinaldehyde to retinoic acid a bioactive form of vitamin A. It has a known mass of approximately 56 kDa. ALDH1A2 has high expression in multiple tissues including the liver pancreas and various types of epithelial cells. This enzyme is cytosolic actively contributing to local retinoid metabolism.
Biological function summary
ALDH1A2 is essential in embryonic development and tissue differentiation. It acts by regulating the levels of retinoic acid necessary for directing gene expression. ALDH1A2 activity is not known to be part of a complex but interacts with other retinoid-binding proteins to achieve its functions. It orchestrates cellular processes by modulating growth factors that are sensitive to retinoic acid.
Pathways
ALDH1A2 is a participant in the retinol metabolism pathway and the broader RA-signaling pathway. It ensures the generation of retinoic acid critical for gene regulation within these pathways. RALDH2's activity is closely related to other dehydrogenases and aldehyde oxidases that contribute to retinoid homeostasis. The interplay with these proteins emphasizes its role in ensuring a balanced retinoic acid supply.
ALDH1A2 has been implicated in conditions such as congenital diaphragmatic hernia and certain cancer types like breast cancer. Aberrant regulation or mutations in ALDH1A2 can lead to altered retinoic acid levels affecting cell proliferation and differentiation pathways. Networks involving ALDH1A2 with proteins like CYP26B1 responsible for retinoic acid catabolism highlight its involvement in these medical conditions.