Abcam, ab75832, Anti-Gelsolin plasma antibody [EPR1941Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GELS antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1941Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The antibody only detects the isoform 1 of the protein (86kDa).

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gelsolin plasma also known as plasma gelsolin is a multifunctional actin-binding protein. It has a molecular mass of approximately 86 kDa. Gelsolin plasma severs and caps actin filaments playing a critical role in the reorganization of the actin cytoskeleton. It is expressed in the cytoplasm and secreted into the blood plasma facilitating actin filament turnover and cellular motility. It also binds to phosphatidylinositol 45-bisphosphate (PIP2) which affects its activity and regulation.
Biological function summary
Gelsolin plasma significantly impacts cell shape movement and signaling. It dismantles actin polymers converting them into monomeric actin important for maintaining the dynamic equilibrium of actin filaments. Gelsolin plasma also participates in the immune response and inflammation modulation. While not specifically part of a larger protein complex it interacts with other cytoskeletal elements and signaling molecules.
Pathways
The functions of gelsolin plasma integrate primarily in the actin cytoskeleton regulation pathway and PIP2 signaling pathway. In the actin cytoskeleton pathway it works alongside proteins such as cofilin and profilin to mediate actin dynamics. In the PIP2 signaling pathway gelsolin plasma interacts with PIP2 which influences its ability to modulate actin filament assembly and disassembly. These pathways are essential for processes like cell migration and cellular signaling.
Gelsolin plasma shows involvement in conditions such as familial amyloidosis and inflammation-related diseases. Mutations in gelsolin can lead to familial amyloidosis of the Finnish type characterized by gelsolin-derived amyloid deposits. Moreover alterations in gelsolin levels relate to inflammatory disorders affecting the body's response to injury and infection. The protein also links to other amyloidogenic proteins emphasizing its role in amyloidosis pathology.