Abcam, ab76159, Anti-Nicotinic Acetylcholine Receptor beta/CHRNB1 antibody [EP2067Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Nicotinic Acetylcholine Receptor beta/CHRNB1 antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP2067Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nicotinic Acetylcholine Receptor beta known commonly as CHRNB1 or CHRNB forms part of the nicotinic acetylcholine receptors (nAChRs). This receptor is a transmembrane protein channel that participates in the transmission of signals through the synaptic cleft by responding to the neurotransmitter acetylcholine. CHRNB1 has a molecular mass of approximately 58 kDa. Researchers find this receptor member expressed in neuromuscular junctions and in several areas of the central nervous system including the brain and spinal cord providing essential roles in synaptic transmission.
Biological function summary
CHRNB1 functions as a component of the pentameric ion channel complex that forms upon binding with other subunits like the alpha subunit of nAChR. When acetylcholine binds to this channel it permits the flow of cations such as sodium and calcium into cells which leads to depolarization and subsequent neurotransmission. This process is fundamental for various neurological functions including muscle contraction and cognitive processes. The receptor is critical for maintaining the efficiency of synaptic connectivity and signaling.
Pathways
CHRNB1 plays a role in neural pathways such as the cholinergic and dopaminergic pathways influencing neurotransmission and behavior. In the cholinergic pathway nAChRs including CHRNB1 modulate the release of other neurotransmitters and are integral to processes like learning and memory. Additionally associations with proteins like CHRNA1 and CHRNA4 illustrate the receptor's involvement in ensuring proper synaptic signaling and response to neurotransmitters across neural circuits.
Dysfunction or mutations in CHRNB1 correlate with conditions like congenital myasthenic syndromes and may contribute to cognitive disorders such as Alzheimer's disease. In congenital myasthenic syndromes impaired signaling influences muscle function highlighting its neuromuscular importance. Researchers also associate CHRNB1 interactions with amyloid precursor protein (APP) in Alzheimer's disease highlighting the receptor's involvement in neurodegenerative processes and its potential as a therapeutic target for modulating synaptic dysfunction.