Abcam, ab76579, Anti-MST4 + MST3 + STK25 (phospho T174 + T178 + T190) antibody [EP2123Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal STK25 phospho T174 antibody. Suitable for WB and reacts with Human samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP2123Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein kinases MST4 MST3 and STK25 are part of the Ste20 kinase family. MST4 and MST3 are often referred to as serine/threonine-protein kinases 26 and 24 respectively while STK25 is known as Ste20-like kinase. These proteins share a common modular architecture consisting of a kinase domain and various regulatory regions. The molecular masses are approximately 50 kDa for MST4 and MST3 and around 54 kDa for STK25. You can find these proteins expressed in multiple tissues including brain testis and spleen.
Biological function summary
MST4 MST3 and STK25 regulate cell growth proliferation and apoptosis. These proteins interact with various cellular components to form signaling complexes that influence cellular responses. MST3 and MST4 can activate apoptosis signal-regulating kinase 1 (ASK1) which leads to the apoptosis pathway. STK25 plays a role in the Golgi apparatus' functionality affecting cellular trafficking and signal transduction.
Pathways
MST4 MST3 and STK25 are involved in critical signaling pathways like the Hippo pathway and MAPK signaling. Within these pathways MST4 and MST3 together associate with MOB1 and LATS1/2 enhancing their functions. STK25 interacts with STRAD and LKB1 contributing to cell polarity regulation and cellular response to external stimuli.
Altered expression and mutations in MST4 MST3 and STK25 associate with cancer and neurological disorders. Cancer progression links strongly with these kinases' dysregulation due to their role in apoptosis and cell proliferation where MST4 activates CST complex involved in these diseases. Neurodegenerative disorders involve STK25 connected via its regulatory influence on cellular structures and its interactions with Huntington protein influencing disease pathophysiology.