Abcam, ab77269, Anti-CCK1-R antibody

Size: 100µg
Goat Polyclonal CCK1-R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CCKAR aa 200-300.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CCKAR aa 200-300. The exact immunogen used to generate this antibody is proprietary information.P32238

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab77269 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCK1-R also known as the Cholecystokinin receptor is a G-protein coupled receptor. It specifically binds to the gastrointestinal hormone cholecystokinin and is involved in regulating digestive processes. The receptor is expressed in various tissues including the pancreas and small intestine and plays a significant role in facilitating digestive enzyme secretion and bile acid release. CCK1-R has a molecular mass of approximately 45 kDa. The receptor also serves as an important target for the development of CCK antagonists such as lorglumide which can be used to modify its activity.
Biological function summary
The cholecystokinin receptor helps regulate satiety and digestive enzyme secretion. It is not typically part of a larger protein complex. The binding of cholecystokinin to CCK1-R stimulates pancreatic enzyme secretion gallbladder contraction and gastric emptying inhibition. This receptor also plays a role in the modulation of food intake and energy balance mediated through its signaling pathways.
Pathways
The CCK receptor plays an important role within the digestive system's gastrointestinal hormone signaling pathway and the central nervous system's appetite regulation pathway. It interacts with various proteins including the MAP kinase pathway components to mediate physiological responses. Additionally CCK1-R is closely linked with proteins involved in the gallbladder contraction such as motilin which further highlights its contribution to digestive processes.
CCK1-R is associated with obesity and pancreatic disorders. Altered expression or function of this receptor can contribute to metabolic imbalances leading to obesity due to disrupted satiety signaling. In the context of pancreatic disorders CCK1-R is linked to pancreatitis where excessive pancreatic enzyme secretion leads to inflammation. The receptor interacts with proteins such as trypsinogen linking its role in disease progression and highlighting its significance as a therapeutic target.