Abcam, ab78298, Anti-SEL1L antibody

Size: 100µg
Rabbit Polyclonal SEL1L antibody. Suitable for WB and reacts with Human samples. Cited in 34 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SEL1L protein also known as Suppressor/Enhancer of Lin-12-like protein 1 has a molecular mass of approximately 87 kDa. This protein is an important component in various cellular processes. SEL1L exhibits broad expression across different tissues including the pancreas liver and muscle tissues. It interacts with other proteins in the endoplasmic reticulum (ER) to assist in maintaining cellular homeostasis. Through these interactions SEL1L participates directly in managing protein folding and degradation processes.
Biological function summary
The SEL1L protein is critically involved in the ER-associated degradation (ERAD) pathway where it works as part of a complex with other proteins like HRD1. This role allows SEL1L to contribute to the removal of misfolded or damaged proteins from the ER preventing cellular toxicity and dysfunction. In the context of protein quality control SEL1L ensures that only correctly folded proteins proceed to their functional destinations thereby maintaining cellular environment stability and function.
Pathways
SEL1L integrates into the unfolded protein response (UPR) and ERAD processes. The function of SEL1L within these pathways links it to key proteins such as HRD1 and BiP facilitating a critical response mechanism when unprocessed or misfolded proteins accumulate within the ER. By participating in these pathways SEL1L helps in regulating cellular stress responses and preserving protein homeostasis contributing to the proper function of the secretory pathway and cellular stress adaptation.
SEL1L has been associated with conditions such as diabetes and pancreatic cancer. Dysfunction or altered expression of SEL1L can disrupt the regulation of protein homeostasis contributing to misfolded protein accumulation and subsequent cellular stress. In diabetes for example SEL1L interacts with proteins such as XBP1 impacting insulin synthesis and secretion. In pancreatic cancer changes in SEL1L expression are linked with cellular changes and responses within the tumor microenvironment. Understanding SEL1L's roles helps in deciphering the pathology of these disorders and may guide therapeutic strategies.