Abcam, ab78408, Anti-Connexin 45/GJA7/Cx45 antibody [5B9.2]

Size: 50µg
Mouse Monoclonal Connexin 45/GJA7/Cx45 antibody. Suitable for ICC, Flow Cyt and reacts with Rat, Human samples. Cited in 10 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:5B9.2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Epitope:Near C terminal, cytoplasmic.

Product details:
This product was changed from ascites to tissue culture supernatant on 17th May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Purified from TCS., Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1.45% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Connexin 45 also known as Cx45 or GJA7 is a gap junction protein that enables cellular communication by forming channels between adjacent cells. The channels regulate ion and small molecule passage which is critical for maintaining cellular homeostasis. Cx45 has a molecular weight of approximately 45 kDa. This protein expresses in various tissues including the heart brain and smooth muscle indicating its diverse physiological roles.
Biological function summary
Cx45 plays an integral role in intercellular communication by participating in the formation of gap junction channels. It functions as part of the connexin family forming homomeric and heteromeric hemichannels that dock with hemichannels on adjacent cells. This connection is essential for electronic coupling and synchronous activity especially in the cardiac and neural tissues where timely communication is necessary for function.
Pathways
Cx45 contributes significantly to the cardiac conduction system and neural transmission pathways. In cardiac tissues it coordinates with connexin 43 to control electrical signal propagation and regulate heartbeat. Cx45 participates in neural pathways by forming functional networks that support synaptic transmission and neuronal synchronization thereby interacting with proteins like connexin 36.
Mutations or dysregulation of Cx45 associate with cardiac arrhythmias and neurological disorders like epilepsy. In the heart Cx45 along with connexin 43 is essential for maintaining normal cardiac rhythm and disturbances can lead to arrhythmogenic conditions. In the nervous system Cx45 dysfunction can affect neural circuitry contributing to epileptic seizures. It is vital to investigate the role of Cx45 in these conditions for developing therapeutic strategies.