Abcam, ab79036, Anti-CUEDC2 antibody

Size: 100µg
Rabbit Polyclonal CUEDC2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CUEDC2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CUEDC2. The exact immunogen used to generate this antibody is proprietary information.Q9H467,
Specificity:ab79036 will not cross-react with CUEDC1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab79036 is purified by affinity chromatography via a peptide column, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CUEDC2 also known as CUE domain-containing 2 is an intracellular protein with a molecular mass of approximately 45 kDa. It has a CUE domain which often associates with ubiquitin-binding. This protein is widely expressed in various tissues notably in the liver placenta and kidney. As a component of cellular machinery CUEDC2 plays a significant role in modulating cellular functions.
Biological function summary
The functions of CUEDC2 touch on several cellular processes including inflammation and cell cycle regulation. The protein can modulate signal transduction pathways by influencing transcription factors. It interacts with the anaphase-promoting complex/cyclosome (APC/C) controlling the ubiquitination and degradation of cell cycle proteins. CUEDC2 through these interactions influences the maintenance of cell cycle checkpoints and contributes to the controlled progression of cells through different stages of the cell cycle.
Pathways
CUEDC2 is integral to the NF-kappaB signaling pathway which is a critical mediator of inflammatory responses. CUEDC2 also participates in the c-Jun N-terminal kinase (JNK) pathway. In these contexts CUEDC2 interacts with proteins such as IKK and JNK to regulate the activation and suppression of downstream targets. These interactions highlight its role in maintaining cellular homeostasis and responding to external stimuli.
Researchers associate CUEDC2 with cancer and inflammatory diseases. In cancer the protein modulates pathways critical for tumor growth and invasion suggesting a possible role in tumorigenesis. CUEDC2's interactions with proteins like IKK and components of the APC/C link it to disorders characterized by aberrant cell proliferation and survival. This makes CUEDC2 a potential therapeutic target in developing treatments for related pathological conditions.