Abcam, ab79516, Anti-GPCR GPR32 antibody

Size: 100µg
Rabbit Polyclonal GPCR GPR32 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human GPR32.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GPR32. The exact immunogen used to generate this antibody is proprietary information.O75388

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
G protein-coupled receptor 32 (GPR32) also known as GPR32 is a member of the G protein-coupled receptors (GPCRs) family characterized by its seven-transmembrane domain structure. The molecular mass of GPR32 is approximately 40 kDa. Researchers typically find GPR32 expression in human tissues such as lung and heart. The receptor interacts with specific ligands activating intracellular signaling pathways that lead to various cellular responses.
Biological function summary
GPR32 plays a role in the immune system regulation and inflammation resolution. It partners with ligand molecules like certain specialized pro-resolving mediators (SPMs) to facilitate anti-inflammatory responses. Scientists study GPR32 as part of the broader network of GPCRs known for their involvement in transmitting signals from the extracellular environment into the cell. By influencing resolution pathways GPR32 helps maintain tissue homeostasis.
Pathways
GPR32 significantly influences the resolution phase of inflammation and integrates into the SPM signaling pathway. It interacts with other proteins such as the ALX/FPR2 receptor which is also known to mediate anti-inflammatory actions. Through these interactions GPR32 contributes to orchestrating inflammatory pathway modulation a critical process for balancing immune responses and promoting tissue repair.
GPR32 has a reported relation with inflammatory conditions and cardiovascular diseases. Researchers have studied its role in chronic inflammation where disrupted regulation might contribute to pathological inflammation persistence. GPR32's involvement in cardiovascular diseases links it to the regulation of blood pressure and vascular inflammation with potential interactions seen with proteins such as NADPH oxidase known to affect oxidative stress within these conditions.