Abcam, ab79559, Anti-CD81 antibody [M38]

Size: 100µg
Anti-CD81 antibody [M38] (ab79559) is a mouse monoclonal antibody detecting CD81 in Western Blot, Flow Cytometry, IHC-P . Suitable for Human . - KO validated for confirmed specificity - Over 140 publications - Trusted since 2009
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:M38,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing CD81 protein. The exact immunogen used to generate this antibody is proprietary information.P60033

Product details:
Product Specifications
Anti-CD81 antibody [M38] (ab79559) is a mouse monoclonal antibody and is validated for use in Flow Cyt, IHC-P, WB in human samples.
Anti-CD81 antibody [M38] (ab79559) specifically detects CD81 (UniProt ID: P60033; Molecular weight: 26kDa) and is sold in 100 µg selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-CD81 antibody [M38] (ab79559) has high sensitivity and specificity.
The specificity of Anti-CD81 antibody [M38] (ab79559) has been confirmed by testing in knockout samples.
Anti-CD81 antibody [M38] (ab79559) has been cited over 142 times in peer reviewed journals and is trusted by the scientific community.
Related Products
Antibody clone M38 is also available pre-conjugated to a variety of labels for your convenience - APC/Cy7®, APC, Biotin, FITC, HRP (
ab200565
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Target Information
CD81 or TAPA1 is a tetraspanin protein that plays a significant role in oncology, particularly in the context of cancer cell proliferation and metastasis. CD81 or TAPA1 is highly expressed in several types of cancer cells and it is involved in various cellular processes, including cell adhesion, migration, and signal transduction. CD81 also contributes to the tumor microenvironment by facilitating interactions between cancer cells and their surroundings.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-ab79559 is purified from hybridoma culture supernatant by protein A affinity chromatography. Purity is > 95% (by SDS-PAGE)., Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD81 also known as TAPA-1 or 26 kDa protein is a member of the tetraspanin family featuring four transmembrane domains. The molecular weight of CD81 is approximately 26-28 kDa. This protein exhibits expression in numerous cell types such as leukocytes endothelial cells and epithelial tissues. CD81 plays a mechanical role by facilitating membrane protein interactions and contributing to cellular processes like adhesion and morphogenesis. Researchers have identified specific isoforms like M38 and labels like 1D6 CHAN in studies involving this target often analyzing CD81 through techniques like Western blot to determine expression levels and molecular weight.
Biological function summary
CD81 interacts with other tetraspanins and forms complexes within the membrane to regulate cellular signaling trafficking and adhesion. It participates in the assembly of larger tetraspanin-enriched microdomains which are important for efficient signaling and functional variety. These complexes modulate cell morphology proliferation and development influencing immune responses and pathogen entry to cells. The presence of CD81 in diverse tissues implies its involvement in a wide range of cellular processes forming essential complexes with proteins like integrins that further engage in tissue repair and immunological defense.
Pathways
CD81 plays significant roles in the immune system and viral entry pathways. It interacts with other proteins like CD9 and CD19 within the immune response pathways regulating lymphocyte activation and differentiation. CD81 is notably a coreceptor in the hepatitis C virus (HCV) entry pathway facilitating viral attachment and fusion into host cells. These interactions illustrate CD81's involvement in modulation of immune cell responses and influence on pathogen infection processes integrating into the complex cellular pathways important for maintaining homeostasis and response to external stimuli.
CD81 has connections to hepatitis C virus (HCV) infections and immunological disorders such as systemic lupus erythematosus (SLE). During HCV infection CD81 serves as an important entry point for the virus interacting with proteins like claudin-1 and scavenger receptor class B type I (SR-BI) enabling viral entry and replication within liver cells. In SLE alterations in CD81 expression can impact autoantibody production and lymphocyte behavior contributing to the disease's pathology. Understanding CD81's role in these diseases provides insight into therapeutic targets and potential interventions for managing infections and autoimmune responses.