Abcam, ab80264, Anti-FJX1 antibody

Size: 100µL
Rabbit Polyclonal FJX1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Four-jointed box protein 1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Four-jointed box protein 1. The exact immunogen used to generate this antibody is proprietary information.Q86VR8

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FJX1 protein also known as Four Jointed Box 1 is a signaling protein with a mass of approximately 53 kDa. It plays a significant role in cellular processes through its mechanistic function as a regulator of cell polarity and growth. Researchers have observed FJX1 expression in various tissues including the brain liver and developing skeletal muscle. Its activity is important during embryonic development where it influences morphogenetic movements and cellular orientation.
Biological function summary
Four Jointed Box 1 interacts with core signaling pathways that affect developmental processes and tissue function. The protein is not directly part of a larger complex but interacts with other molecules to perform its function. Its presence influences planar cell polarity impacting how cells orient themselves within a plane of tissue. This regulation is important for correct tissue structure and function which affects how organs develop and maintain their physiological roles.
Pathways
FJX1 is part of the Wnt/planar cell polarity (PCP) signaling pathway. This pathway plays a critical role in developmental processes like neural tube closure and cochlea orientation. It also interacts with the Fat/Ds signaling axis closely related to the Dachsous and Fat atypical cadherins which highlights its role in cell communication and signal transduction critical for maintaining cell orientation and polarity within tissues.
Abnormalities in FJX1 expression or function relate to disorders like congenital heart defects and scoliosis. Studies have shown that disturbances in the Wnt/PCP pathway can lead to these conditions implicating FJX1 in their pathogenesis. Additionally through these pathways FJX1 interacts with proteins such as Van Gogh-like 2 which further emphasizes its role in maintaining proper tissue development and alignment during both embryonic and adult phases.