Abcam, ab81618, Anti-FAM91A1 antibody

Size: 100µL
Rabbit Polyclonal FAM91A1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FAM91A1 aa 300-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FAM91A1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.Q658Y4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab81618 was affinity purified using an epitope specific to FAM91A1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein FAM91A1 also known as Family with Sequence Similarity 91 Member A1 is involved in intracellular processes related to membrane trafficking. It has an approximate molecular mass of 67 kDa. Its expression is mainly observed in tissues like the brain where it may play a role in neurodevelopment. Although its distribution is widespread higher expression levels occur in tissues with dynamic intracellular transit such as the kidney and liver.
Biological function summary
This protein participates in cellular functions that involve endosomal trafficking and recycling. FAM91A1 interacts with other proteins to form complexes that regulate cargo sorting within cells. Its mechanical involvement in vesicular transport is important for maintaining cellular homeostasis. Due to its interaction with several membrane-coupled proteins it influences cellular organization and signaling.
Pathways
FAM91A1 is involved in the endocytic pathway and the lysosomal pathway. It collaborates with proteins such as Rab GTPases which are key regulators of vesicular transport. The connection of FAM91A1 to these pathways reflects its role in determining the fate of endocytosed material and influencing lysosome-related processes. It also interfaces with clathrin-coated vesicle components facilitating endosome maturation and delivery to lysosomes.
FAM91A1 has connections to neurodegenerative diseases and cancer. Studies suggest that its dysregulation can contribute to Alzheimer's disease through interaction with proteins like amyloid precursor protein (APP) impacting amyloid-beta processing. Additionally its altered expression is observed in certain cancers linking it to proteins involved in tumor metastasis such as matrix metalloproteinases. These connections underline its potential as a biomarker in disease diagnosis and therapy.